Awesome Serum Sickness Like Reaction

What is a serum sickness like reaction. A serum sickness like reaction sslr to drug administration usually consists of cutaneous rash arthralgia arthritis and often fever.

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Serum Sickness And Serum Sickness Like Reaction Pediatrics Clerkship The University Of Chicago Serum The University Of Chicago Pediatrics

A serum sickness like reaction clinically similar to classical serum sickness can result from the administration of a number of non protein drugs such as tetracyclines penicillins cephalosporins 116.

Serum sickness like reaction. Such generalized serum sickness like reactions were common in the era when horse serum was used to treat or prevent many infectious diseases and when very large quantities of immunogenic foreign protein were infused sometimes repeatedly. A serum sickness like reaction is very similar to serum sickness but it involves a different type of immune response. It s much more common than actual.

This entity rarely has been discussed in the dermatologic literature. Treatment is typically symptomatic but hospitalization may be required for severe cases. Serum sickness in humans is a reaction to proteins in antiserum derived from a non human animal source occurring 5 10 days after exposure.

While optimal treatment strategies for serum sickness like reactions are not clearly defined in the literature discontinuation of the suspected agent combined with use of antihistamines corticosteroids and nsaids for symptom control is an appropriate therapeutic route. It was first characterized by clemens von pirquet and béla schick in 1906. These reactions require both igg antibody and circulating excess antigen.

True serum sickness caused by immune complex formation in response to foreign heterologous protein exposure. It is a type of hypersensitivity specifically immune complex hypersensitivity. The term serum sickness like reaction is occasionally used to refer to similar illnesses that arise from the introduction of certain non protein substances such as penicillin.

Serum sickness like reaction sslrs which are more common in children can cause a similar but less severe clinical picture without measurable immune complex formation. The onset of serum sickness like reaction is usually 1 3 weeks can be as early as 1 2 days after exposure to the medication. Serum sickness is a rare allergic reaction to heterologous or foreign protein or serum usually in response to an injection.

Serum sickness like reactions have unclear pathogenic mechanism but do not involve immune complexes. Serum sickness and serum sickness like reactions have very similar symptoms and differ mainly by their pathogeneses. Illnesses immunisations and occasionally chemicals can also trigger sslrs.

They are triggered by a variety of drugs most commonly cefaclor and amoxicillin. Clinical features of serum sickness like reaction. Minocycline has been reported to cause serum sickness 78 117.

Serum sickness is an immune complex mediated hypersensitivity reaction or type 3 hypersensitivity reaction that it is characterized by symptoms such as fever skin rash pain and swelling in one or more joints and kidney damage 1. Urticaria or hive like lesions that last minutes to hours reappearing elsewhere. Serum sickness like reaction is an acute self limited reaction with an ultimately favorable outcome.

The rash associated with serum sickness like reaction is usually. We describe the case of a 3 year old girl with urticaria fever and arthralgia that appeared 8 days after starting cefaclor therapy for.

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