Cool Insulin Like Growth Factors

The insulin like growth factors igfs are peptides with a high sequence homology with insulin which are part of a complex system often referred to as the igf axis that has a role in the promotion of cell proliferation and in the inhibition of apoptosis. Igfs were discovered when investigators began studying the effects of biological substances on cells and tissues outside the body.

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Insulin like growth factor 1 receptor igf 1r is a membrane tyrosine kinase receptor with a 70 homology to the insulin receptor that when activated by its ligands igf 1 igf 2 or insulin at supraphysiological concentrations.

Insulin like growth factors. The insulin like growth factors are proteins with high sequence similarity to insulin. Insulin like growth factor igf formerly called somatomedin any of several peptide hormones that function primarily to stimulate growth but that also possess some ability to decrease blood glucose levels. Insulin like growth factors igfs are mitogens that share structural homology with proinsulin and are involved in the growth and development of many organs including lung.

The regulation of igf action depends not only on the expression of igfs and igf receptors but also on the modulation of igf activity by igf binding proteins igfbps. This complex system consists of two cell surface receptors two ligands a family of seven high affinity igf binding proteins as well as associated igfbp degrading enzymes referred to collectively as proteases. Igfs are part of a complex system that cells use to communicate with their physiologic environment.

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